BAM-15 3000mg (50mg/capsule)
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BAM-15 is a synthetic mitochondrial uncoupling compound studied for its molecular properties, with particular research interest in its interactions with proton transport mechanisms in experimental models. As a chemical uncoupler, it is studied for its capacity to dissociate the mitochondrial proton gradient from ATP… CAS: 210302-17-3 | Formula: C16H10F2N6O | Content: 3000mg (50mg per capsule) | Research use only | Third-party lab tested.
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BAM-15 3000mg (50mg/capsule) — Research Overview
BAM-15 is a synthetic mitochondrial uncoupling compound studied for its molecular properties, with particular research interest in its interactions with proton transport mechanisms in experimental models. As a chemical uncoupler, it is studied for its capacity to dissociate the mitochondrial proton gradient from ATP synthesis, distinguishing its mechanism from classical uncouplers in comparative bioenergetics research. Research applications include mitochondrial bioenergetics studies, proton transport pathway research, and comparative uncoupler pharmacology.
- High Purity – 99% Purity Guaranteed
- Independently Lab Tested
- Research Grade Quality
- For Laboratory Research Use Only
Intended use: This material is supplied for laboratory and in-vitro research only. It is not a drug, food, or cosmetic and is not intended for human or animal consumption.
BAM-15 3000mg (50mg/capsule) Chemical Properties
| Property | Specification |
|---|---|
| Chemical Formula | C16H10F2N6O |
| Synonyms | N5,N6-bis(2-fluorophenyl)-;BAM 15 (N5,N6-bis(2-Fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine) |
| Molar Mass | 340.29 g/mol |
| CAS Number | 210302-17-3 |
| PubChem CID | 565708 |
| Total Compound Content | 3000mg (50mg per capsule) |
| Shelf Life | 36 months |
BAM-15 3000mg (50mg/capsule) Research Applications
BAM-15 is studied for its activity as a synthetic mitochondrial uncoupling compound, with laboratory research demonstrating specific interactions with proton transport mechanisms in experimental models. As a chemical protonophore-class research tool, BAM-15 is examined for its capacity to dissipate the inner mitochondrial membrane proton gradient independent of ATP synthase activity, a mechanism studied using oxygen consumption rate assays and mitochondrial membrane potential measurements in cell-based and isolated mitochondria models. Comparative bioenergetics research has examined BAM-15 relative to other chemical uncouplers, with particular research interest in its selectivity profile for mitochondrial versus plasma membrane effects. Independently third-party HPLC-tested; COA available per batch.
BAM-15 3000mg (50mg/capsule) Frequently Asked Questions
What oxygen consumption rate assays are used to characterise BAM-15’s mitochondrial uncoupling activity?
Extracellular flux analyzers (Seahorse-type respirometry platforms) and Clark-type oxygen electrodes are standard tools for measuring BAM-15’s effect on oxygen consumption rate (OCR) in cell-based and isolated mitochondria preparations. Researchers typically measure basal respiration, then introduce BAM-15 to assess the magnitude of uncoupled respiration (oxygen consumption not coupled to ATP synthesis), followed by oligomycin and electron transport chain inhibitor titrations to fully resolve the bioenergetic profile and confirm the proton transport mechanism.
How is BAM-15’s mitochondrial membrane potential effect measured in cell-based research models?
Fluorescent potentiometric dyes (such as TMRM or JC-1) combined with flow cytometry or fluorescence microscopy are used to measure changes in mitochondrial membrane potential following BAM-15 exposure, allowing researchers to quantify the degree of proton gradient dissipation across a concentration range. These measurements are typically paired with parallel ATP level assays to characterise the relationship between membrane potential changes and downstream bioenergetic consequences in the specific cell model under study.
What comparative research has examined BAM-15 against other chemical mitochondrial uncouplers?
Comparative bioenergetics research has examined BAM-15 relative to other protonophore-class compounds, with particular research interest in selectivity profiles distinguishing effects on the mitochondrial inner membrane from effects on the plasma membrane. Such studies typically employ parallel OCR and membrane potential assays across multiple uncoupler compounds at matched concentrations, allowing researchers to characterise relative potency, selectivity windows, and structure-activity relationships within this compound class.
Research Use Disclaimer
All product information is provided for educational and laboratory research reference only. Any form of introduction into humans or animals is prohibited. Handle only in licensed research settings in accordance with applicable laws and institutional protocols.
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