SR-9011 (5mg/capsule), 60 Capsules
Original price was: $99.95.$85.95Current price is: $85.95.
SR-9011 is a synthetic small-molecule agonist of the nuclear receptors REV-ERBα (NR1D1) and REV-ERBβ (NR1D2), members of the nuclear receptor superfamily that function as ligand-dependent transcriptional repressors. Activation of REV-ERB receptors influences transcriptional regulatory networks through recruitment of… CAS: 1379686-29-9 | Formula: C23H31ClN4O3S | Content: 300 mg (5 mg per capsule) | Research use only | Third-party lab tested.
Buy SR-9011 (5mg/capsule), 60 Capsules – Swiss Chems USA
SR-9011 (5mg/capsule), 60 Capsules — Research Overview
SR-9011 is a synthetic small-molecule agonist of the nuclear receptors REV-ERBα (NR1D1) and REV-ERBβ (NR1D2), members of the nuclear receptor superfamily that function as ligand-dependent transcriptional repressors. Activation of REV-ERB receptors influences transcriptional regulatory networks through recruitment of corepressor complexes, including NCoR and HDAC3, resulting in suppression of target gene expression. Experimental investigations have examined SR-9011 in studies of circadian clock regulation, transcriptional control mechanisms, nuclear receptor signaling, and coordinated gene regulatory networks. Research applications include REV-ERB pharmacology, circadian rhythm signaling investigation, transcriptional regulation studies, nuclear receptor biology, and mechanistic evaluation of circadian-associated regulatory systems.
- High Purity – 99% Purity Guaranteed
- Independently Lab Tested
- Research Grade Quality
- For Laboratory Research Use Only
Intended use: This material is supplied for laboratory and in-vitro research only. It is not a drug, food, or cosmetic and is not intended for human or animal consumption.
SR-9011 (5mg/capsule), 60 Capsules Chemical Properties
| Property | Specification |
|---|---|
| Chemical Formula | C23H31ClN4O3S |
| Synonyms | SR9011, REV-ERBα/β agonist |
| Molar Mass | 479.0 g/mol |
| CAS Number | 1379686-29-9 |
| PubChem CID | 57394021 |
| Total Compound Content | 300 mg (5 mg per capsule) |
| Shelf Life | 36 months |
SR-9011 (5mg/capsule), 60 Capsules Research Applications
SR-9011 is a synthetic dual agonist of REV-ERBα (NR1D1) and REV-ERBβ (NR1D2), nuclear receptors that function as transcriptional repressors within circadian and metabolic regulatory networks. Activation of REV-ERB receptors promotes recruitment of corepressor complexes, including NCoR and HDAC3, resulting in suppression of target gene transcription and modulation of downstream regulatory pathways. Experimental investigations have examined SR-9011 in studies of circadian clock signaling, transcriptional control mechanisms, nuclear receptor pharmacology, and coordinated gene regulatory networks. Its activity at both REV-ERB receptor subtypes makes it a valuable research tool for investigating transcriptional repression, receptor-cofactor interactions, circadian-associated signaling pathways, and mechanistic aspects of REV-ERB-mediated gene regulation. Supplied in 5 mg capsules. Independently third-party HPLC-tested; COA available per batch.
SR-9011 (5mg/capsule), 60 Capsules Frequently Asked Questions
How does SR-9011 affect REV-ERB-mediated transcriptional regulation?
SR-9011 is a dual agonist of REV-ERBα and REV-ERBβ, nuclear receptors that function as transcriptional repressors within gene regulatory networks. Activation of REV-ERB receptors promotes recruitment of corepressor complexes to response elements within target genes, resulting in suppression of transcriptional activity. This mechanism makes SR-9011 a valuable research tool for investigating transcriptional repression, receptor-cofactor interactions, and nuclear receptor-mediated gene regulation.
What makes SR-9011 useful for REV-ERB pharmacology research?
SR-9011 activates both REV-ERBα and REV-ERBβ, providing a single molecular tool for studying coordinated REV-ERB receptor signaling. Experimental investigations have utilized SR-9011 to examine receptor activation mechanisms, transcriptional control processes, circadian-associated regulatory pathways, and interactions between nuclear receptors and corepressor complexes. Its dual-receptor profile makes it particularly useful for comparative studies of REV-ERB-mediated signaling systems.
What are the primary research applications of SR-9011?
SR-9011 is widely used in studies of REV-ERB pharmacology, circadian-associated signaling networks, transcriptional regulation, and nuclear receptor biology. Research applications include investigation of receptor-mediated gene repression, response element regulation, cofactor recruitment mechanisms, and coordinated regulatory pathways controlled by REV-ERB receptors. These characteristics make SR-9011 a valuable tool for mechanistic studies of transcriptional control and nuclear receptor signaling systems.
Research Use Disclaimer
All product information is provided for educational and laboratory research reference only. Any form of introduction into humans or animals is prohibited. Handle only in licensed research settings in accordance with applicable laws and institutional protocols.
| Weight | 3 lbs |
|---|
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