Levothyroxine T4 (0.2mg/60caps)
$59.95
Levothyroxine (L-thyroxine, T4) is an iodinated amino acid derivative utilized as a reference compound in studies of thyroid hormone biochemistry, metabolism, and signaling. It serves as a substrate for deiodinase enzymes (DIO1, DIO2, and DIO3), which catalyze selective deiodination reactions and regulate downstream… CAS: 51-48-9 | Formula: C15H11I4NO4 | Content: 12 mg (0.2 mg per capsule) | Research use only | Third-party lab tested.
Buy Levothyroxine T4 (0.2mg/60caps) – Swiss Chems USA
Levothyroxine T4 (0.2mg/60caps) — Research Overview
Levothyroxine (L-thyroxine, T4) is an iodinated amino acid derivative utilized as a reference compound in studies of thyroid hormone biochemistry, metabolism, and signaling. It serves as a substrate for deiodinase enzymes (DIO1, DIO2, and DIO3), which catalyze selective deiodination reactions and regulate downstream thyroid hormone-associated molecular pathways. Experimental investigations have employed T4 in studies of deiodinase enzymology, thyroid hormone transport proteins, nuclear receptor signaling, transcriptional regulation, metabolic pathway modulation, and endocrine signaling networks. Its well-characterized biochemical properties make it a valuable research tool for investigations of thyroid hormone metabolism, deiodinase-dependent conversion mechanisms, receptor-mediated signaling pathways, and comparative analyses of thyroid hormone-associated molecular processes. Supplied in capsule format.
- High Purity – 99% Purity Guaranteed
- Independently Lab Tested
- Research Grade Quality
- For Laboratory Research Use Only
Intended use: This material is supplied for laboratory and in-vitro research only. It is not a drug, food, or cosmetic and is not intended for human or animal consumption.
Levothyroxine T4 (0.2mg/60caps) Chemical Properties
| Property | Specification |
|---|---|
| Chemical Formula | C15H11I4NO4 |
| Synonyms | Thyroxine, L-Thyroxine, T4, Synthroid (trade name), Levothroid (trade name) |
| Molar Mass | 776.87 g/mol |
| CAS Number | 51-48-9 |
| PubChem CID | 5819 |
| Total Compound Content | 12 mg (0.2 mg per capsule) |
| Shelf Life | 36 months |
Levothyroxine T4 (0.2mg/60caps) Research Applications
Levothyroxine (L-3,3′,5,5′-tetraiodothyronine; T4) is a tetraiodinated thyronine utilized as a reference compound in studies of iodothyronine biochemistry, deiodinase enzymology, and nuclear receptor signaling. It serves as a substrate for the iodothyronine deiodinase enzyme family (DIO1, DIO2, and DIO3), which catalyze selective deiodination reactions and regulate downstream iodothyronine-associated molecular pathways. Experimental investigations have employed T4 in studies of deiodinase-catalyzed conversion mechanisms, transport dynamics, nuclear receptor activation, transcriptional regulation, metabolic pathway modulation, and signal transduction processes. Its well-characterized biochemical properties make it a valuable research tool for investigations of iodothyronine metabolism, deiodinase-dependent molecular mechanisms, receptor-mediated signaling pathways, and comparative analyses of iodinated thyronine compounds. Independently third-party HPLC-tested; COA available per batch.
Levothyroxine T4 (0.2mg/60caps) Frequently Asked Questions
Why is T4 considered a precursor molecule rather than the primary active iodothyronine?
T4 exhibits lower affinity for thyroid hormone receptors than T3 and functions primarily as a substrate for deiodinase-mediated conversion pathways. Its biological significance is largely derived from enzymatic deiodination by DIO1 and DIO2, which generate T3 and thereby regulate downstream receptor-associated signaling. This relationship makes T4 a valuable research tool for investigating deiodinase-dependent activation mechanisms, iodothyronine metabolism, and the regulation of receptor-accessible signaling molecules.
How do DIO1 and DIO2 differ in iodothyronine metabolism studies?
DIO1 and DIO2 both catalyze outer-ring deiodination of T4 to T3 but differ in their kinetic properties, substrate handling characteristics, and regulatory roles within iodothyronine metabolism. DIO1 is commonly investigated in studies of bulk iodothyronine turnover and circulating metabolite generation, whereas DIO2 is frequently examined as a regulator of localized intracellular T3 production. Comparative analysis of these enzymes is central to understanding deiodinase-dependent control of iodothyronine signaling pathways and metabolic regulation.
What distinguishes T4 from T3 in deiodinase and receptor-signaling research?
T4 is primarily utilized as a substrate for deiodinase-mediated conversion studies, allowing investigation of enzymatic activation pathways and regulation of iodothyronine metabolism. T3, by contrast, directly engages thyroid hormone receptors without requiring prior deiodination. As a result, T4 is commonly employed in studies examining deiodinase activity, substrate conversion kinetics, and iodothyronine metabolic pathways, while T3 is used in experiments focused on direct receptor activation and downstream transcriptional signaling mechanisms.
Research Use Disclaimer
All product information is provided for educational and laboratory research reference only. Any form of introduction into humans or animals is prohibited. Handle only in licensed research settings in accordance with applicable laws and institutional protocols.
| Weight | 4 lbs |
|---|
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