Clomiphene, 1500mg (25mg/capsule)
Original price was: $79.95.$69.95Current price is: $69.95.
Clomiphene is a racemic mixture of two geometric isomers of a triphenylethylene selective oestrogen receptor modulator (SERM): enclomiphene (trans-isomer, predominant ER antagonist) and zuclomiphene (cis-isomer, mixed ER agonist/antagonist). The racemic mixture has a well-characterised clinical pharmacological profile… CAS: 50-41-9 | Formula: C32H36ClNO8 | Content: 1,500 mg (25 mg per capsule) | Research use only | Third-party lab tested.
Buy Clomiphene, 1500mg (25mg/capsule) – Swiss Chems USA
Clomiphene, 1500mg (25mg/capsule) — Research Overview
Clomiphene is a racemic mixture of two geometric isomers of a triphenylethylene selective oestrogen receptor modulator (SERM): enclomiphene (trans-isomer, predominant ER antagonist) and zuclomiphene (cis-isomer, mixed ER agonist/antagonist). The racemic mixture has a well-characterised clinical pharmacological profile as a SERM used to investigate hypothalamic–pituitary–gonadal axis feedback. Research applications include SERM pharmacology, HPG-axis feedback investigation, and isomeric mixture vs. isolated isomer comparative studies.
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- For Laboratory Research Use Only
Intended use: This material is supplied for laboratory and in-vitro research only. It is not a drug, food, or cosmetic and is not intended for human or animal consumption.
Clomiphene, 1500mg (25mg/capsule) Chemical Properties
| Property | Specification |
|---|---|
| Chemical Formula | C32H36ClNO8 |
| Synonyms | Clomiphene citrate salt, 2-(4-[2-Chloro-1,2-diphenylethenyl]phenoxy)-N,N-diethylethanamine, Clostilbegit, Dyneric, Klostilbegit, Serophene |
| Molar Mass | 598.1 g/mol |
| CAS Number | 50-41-9 |
| PubChem CID | 60974 |
| Total Compound Content | 1,500 mg (25 mg per capsule) |
| Shelf Life | 36 months |
Clomiphene, 1500mg (25mg/capsule) Research Applications
Clomiphene is a synthetic triphenylethylene compound supplied as a racemic mixture of two geometric isomers: enclomiphene (~38% of mixture; trans-isomer, predominantly ER antagonist, t½ ~10 hours) and zuclomiphene (~62% of mixture; cis-isomer, mixed ER agonist-antagonist, t½ ~30 days). The combined profile — transient ER antagonism from enclomiphene plus prolonged background ER activity from zuclomiphene — produces a net increase in LH and FSH secretion via hypothalamic-pituitary ER de-repression, though the zuclomiphene accumulation complicates isomer-specific mechanistic attribution. Clomiphene has a long clinical history in reproductive endocrinology, providing extensive pharmacodynamic and safety data. It remains the reference compound for SERM-mediated HPG-axis modulation research, with enclomiphene (separate SKU) available for studies requiring isolated trans-isomer pharmacology without zuclomiphene confound. Supplied in 25 mg capsules. Independently third-party HPLC-tested; COA available per batch.
Clomiphene, 1500mg (25mg/capsule) Frequently Asked Questions
What is the isomeric composition of clomiphene and how does it differ from enclomiphene?
Clomiphene is a racemic mixture of approximately 38% enclomiphene (trans-isomer) and 62% zuclomiphene (cis-isomer). Enclomiphene is predominantly an ER antagonist with a ~10-hour half-life. Zuclomiphene is a mixed ER agonist/antagonist with a ~30-day half-life, leading to accumulation with repeated dosing. SwissChems also supplies isolated enclomiphene (ENCLOMFNE-60) for studies requiring pure trans-isomer pharmacology without the zuclomiphene background.
Why does zuclomiphene’s long half-life complicate mechanistic research with clomiphene?
Zuclomiphene accumulates with repeated dosing (t½ ~30 days vs. enclomiphene’s ~10 hours), creating a progressively increasing background of ER agonist/antagonist activity that is difficult to control or quantify in repeat-dose study designs. This accumulation confounds attribution of pharmacodynamic effects to the enclomiphene component — the presumed primary active isomer for HPG-axis modulation. Researchers studying acute or isomer-specific ER antagonism at the HPG axis typically prefer isolated enclomiphene to avoid this confound.
What is clomiphene’s mechanism of action at the hypothalamic-pituitary axis?
Clomiphene’s primary HPG-axis mechanism is ER antagonism at hypothalamic arcuate nucleus KNDy neurons and pituitary gonadotrophs. Oestrogen-mediated negative feedback normally suppresses GnRH pulsatility and gonadotropin secretion. ER antagonism by clomiphene’s enclomiphene component reduces this negative feedback, increasing GnRH pulse frequency and downstream LH/FSH secretion. The zuclomiphene component provides a counteracting partial ER agonist background that partially offsets this effect, resulting in the net gonadotropin-stimulating profile of the racemic mixture.
Research Use Disclaimer
All product information is provided for educational and laboratory research reference only. Any form of introduction into humans or animals is prohibited. Handle only in licensed research settings in accordance with applicable laws and institutional protocols.
| Weight | 3 lbs |
|---|
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