MK-677 (Ibutamoren), (10mg/capsule) 60 Capsules
Original price was: $89.95.$69.95Current price is: $69.95.
MK-677 (Ibutamoren) is a non-peptide agonist of the growth hormone secretagogue receptor subtype 1a (GHS-R1a). Binding to GHS-R1a activates Gq/11-mediated phospholipase C signaling, leading to IP3 and DAG generation, intracellular calcium mobilization, and downstream signaling cascade activation. Research applications… CAS: 159752-10-0 | Formula: C27H36N4O5S | Research use only | Third-party lab tested.
Buy MK-677 (Ibutamoren), (10mg/capsule) 60 Capsules – Swiss Chems USA
MK-677 (Ibutamoren), (10mg/capsule) 60 Capsules — Research Overview
MK-677 (Ibutamoren) is a non-peptide agonist of the growth hormone secretagogue receptor subtype 1a (GHS-R1a). Binding to GHS-R1a activates Gq/11-mediated phospholipase C signaling, leading to IP3 and DAG generation, intracellular calcium mobilization, and downstream signaling cascade activation. Research applications include receptor pharmacology, ligand-binding dynamics, signal transduction characterization, structure-activity relationship investigations, and comparative studies of GHS-R1a agonist activity.
- High Purity – 99% Purity Guaranteed
- Independently Lab Tested
- Research Grade Quality
- For Laboratory Research Use Only
Intended use: This material is supplied for laboratory and in-vitro research only. It is not a drug, food, or cosmetic and is not intended for human or animal consumption.
MK-677 (Ibutamoren), (10mg/capsule) 60 Capsules Chemical Properties
| Property | Specification |
|---|---|
| Chemical Formula | C27H36N4O5S |
| Synonyms | Ibutamoren, CHEMBL13817, L 163191, L-163,191, CHEMBL542653, 1-(methanesulfonyl)-1′-(2-methyl-L-alanyl-O-benzyl-D-seryl)-1,2-dihydrospiro[indole-3,4′-piperidine] 192511-65-2 |
| Molar Mass | 624.8 g/mol |
| CAS Number | 159752-10-0 |
| PubChem CID | 6450830 |
| Total Active Ingredient | 600 mg (10 mg per capsule) |
| Shelf Life | 36 months |
MK-677 (Ibutamoren), (10mg/capsule) 60 Capsules Research Applications
MK-677 is a spiropiperidine-class, non-peptide GHS-R1a agonist that mimics endogenous ghrelin while demonstrating resistance to peptidase degradation in preclinical models. GHS-R1a engagement activates Gq/11 proteins, stimulating phospholipase C–mediated hydrolysis of PIP2 to IP3 and DAG, leading to intracellular Ca²⁺ mobilisation and activation of somatotroph secretory machinery. Unlike direct GH administration, sustained GHS-R1a agonism preserves the pulsatile architecture of GH release — a distinction of mechanistic importance in studies of GH secretory dynamics. Concurrent elevation of circulating IGF-1 in vivo models reflects intact somatotropic axis responsiveness. Researchers employ MK-677 to investigate GHS-R1a signalling kinetics, hypothalamic somatostatin tone modulation, feedback loop architecture within the GH/IGF-1 axis, and the metabolic consequences of secretagogue-driven GH elevation including nitrogen retention and lipid substrate partitioning. Supplied in 10 mg capsules. Independently third-party HPLC-tested; COA available per batch. Also in our SARMs range: RAD-140 (Testolone) at 10mg/capsule and GW-501516 (Cardarine) at 10mg/capsule, both 60 capsules. Available as a multi-item pack: GW-501516 + RAD-140 + MK-677 Value Pack.
MK-677 (Ibutamoren), (10mg/capsule) 60 Capsules Lab Results & Certificates of Analysis
Third-party analytical reports associated with this research compound:
- SC MK-677 (HPLC) — July 31, 2026 | Verification
- SC MK-677 (Heavy Metal) — June 19, 2026 | Verification
- MK-677 (Heavy Metal) — June 12, 2026 | Verification
- SC MK-677 (HPLC) — June 12, 2026 | Verification
- MK-677 (GC-MS/LC-MS Contamination Screening) — May 17, 2026 | Verification
MK-677 (Ibutamoren), (10mg/capsule) 60 Capsules Frequently Asked Questions
What is the half-life of MK-677 and how does this affect research protocol design?
MK-677 has an elimination half-life of approximately 24 hours in preclinical models, enabling stable plasma concentrations across preclinical protocols. This extended half-life is a key pharmacokinetic distinction from peptide-based GH secretagogues (e.g. GHRP-6, t½ ~15–20 minutes), which require multiple daily administrations to sustain GHS-R1a engagement. For long-duration GH axis studies, the long half-life reduces protocol variability.
What makes MK-677 a useful research tool for studying GHS-R1a signaling?
MK-677 is a non-peptide GHS-R1a agonist that exhibits prolonged receptor occupancy and resistance to enzymatic degradation. These properties allow researchers to investigate receptor activation kinetics, downstream signaling cascades, ligand-receptor interactions, and signal transduction dynamics over extended observation periods. Its well-characterized pharmacological profile has made it a widely used reference compound in GHS-R1a receptor pharmacology research.
How does MK-677 compare to GHRP-6 and GHRP-2 in laboratory models?
All three are GHS-R1a agonists, but MK-677 is a non-peptide small molecule with a ~24-hour half-life. GHRP-6 and GHRP-2 are hexapeptides requiring parenteral administration with half-lives under 30 minutes. GHRP-6 co-stimulates ghrelin-independent appetite pathways; GHRP-2 produces a stronger but shorter GH pulse. MK-677’s sustained receptor occupancy and non-peptide structure support different experimental designs from injectable peptide secretagogues.
Research Use Disclaimer
All product information is provided for educational and laboratory research reference only. Any form of introduction into humans or animals is prohibited. Handle only in licensed research settings in accordance with applicable laws and institutional protocols.
| Weight | 3 lbs |
|---|
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