RAD-140 (Testolone), (10mg/capsule) 60 Capsules
$89.95
RAD-140 (Testolone) is a non-steroidal selective androgen receptor modulator (SARM) of the oxadiazole class, engineered for high-affinity, tissue-selective AR interaction. Radioligand competition assays confirm low-nanomolar Ki for AR, with functional selectivity characterised by differential co-regulator recruitment… CAS: 1182367-47-0 | Formula: C20H16ClN5O2 | Content: 600 mg (10 mg per capsule) | Research use only | Third-party lab tested.
Buy RAD-140 (Testolone), (10mg/capsule) 60 Capsules – Swiss Chems USA
RAD-140 (Testolone), (10mg/capsule) 60 Capsules — Research Overview
RAD-140 (Testolone) is a non-steroidal selective androgen receptor modulator (SARM) of the oxadiazole class, engineered for high-affinity, tissue-selective AR interaction. Radioligand competition assays confirm low-nanomolar Ki for AR, with functional selectivity characterised by differential co-regulator recruitment across tissue types in vitro. Research applications include AR structure–activity relationship studies, tissue-selective transcriptional activation profiling, and androgenic signalling pathway investigation.
- High Purity – 99% Purity Guaranteed
- Independently Lab Tested
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- For Laboratory Research Use Only
Intended use: This material is supplied for laboratory and in-vitro research only. It is not a drug, food, or cosmetic and is not intended for human or animal consumption.
RAD-140 (Testolone), (10mg/capsule) 60 Capsules Chemical Properties
| Property | Specification |
|---|---|
| Chemical Formula | C20H16ClN5O2 |
| Synonyms | 2-chloro-4-(((1R,2S)-1-(5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl)-2-hydroxypropyl)amino)-3-methylbenzonitrile, RAD 140, Testolone |
| Molar Mass | 393.8 g/mol |
| CAS Number | 1182367-47-0 |
| PubChem CID | 44200882 |
| Total Compound Content | 600 mg (10 mg per capsule) |
| Shelf Life | 36 months |
RAD-140 (Testolone), (10mg/capsule) 60 Capsules Research Applications
RAD-140 is a non-steroidal selective androgen receptor modulator (SARM) of the oxadiazole class characterized by high-affinity androgen receptor (AR) binding in the low-nanomolar range. In vitro transactivation assays demonstrate potent AR-mediated transcriptional activity together with ligand-specific co-regulator recruitment patterns, a pharmacological profile that distinguishes RAD-140 from steroidal AR ligands and contributes to its utility in androgen receptor research. The compound lacks a steroid backbone and induces distinct receptor conformations that influence downstream transcriptional responses, making it a valuable tool for investigating AR signaling mechanisms and ligand-dependent receptor behavior. Metabolic characterization indicates oxidative biotransformation followed by conjugation pathways, with clearance profiles documented in experimental systems. Research applications include androgen receptor pharmacology, receptor-coregulator interaction mapping, androgen response element (ARE) activation studies, structure-activity relationship investigations, and comparative analyses of selective androgen receptor modulators. Supplied in 10 mg capsules. Independently third-party HPLC-tested; COA available per batch.
RAD-140 (Testolone), (10mg/capsule) 60 Capsules Lab Results & Certificates of Analysis
Third-party analytical reports associated with this research compound:
RAD-140 (Testolone), (10mg/capsule) 60 Capsules Frequently Asked Questions
How does RAD-140 differ from steroidal androgen receptor ligands in receptor pharmacology research?
RAD-140 is a non-steroidal androgen receptor modulator that binds AR with high affinity while inducing ligand-specific receptor conformations distinct from those produced by steroidal ligands. These conformational differences influence co-regulator recruitment, transcriptional activity, and downstream signaling behavior, making RAD-140 a valuable tool for investigating selective androgen receptor modulation and ligand-dependent receptor dynamics.
Q: What is the half-life of RAD-140 and how is it metabolized?
Pharmacokinetic investigations report an elimination half-life of approximately 60 hours. Metabolic characterization indicates oxidative biotransformation followed by conjugation pathways, with CYP-mediated metabolism contributing to compound clearance. Elimination profiles have been documented in experimental systems through both biliary and renal pathways.
Why is RAD-140 commonly used in androgen receptor signaling research?
RAD-140 combines high-affinity androgen receptor binding with a well-characterized pharmacological profile, making it useful for studies examining receptor activation mechanisms, co-regulator interactions, androgen response element (ARE) signaling, and structure-activity relationships. Its non-steroidal scaffold also makes it a valuable comparator in investigations of ligand-dependent androgen receptor behavior and selective receptor modulation.
Research Use Disclaimer
All product information is provided for educational and laboratory research reference only. Any form of introduction into humans or animals is prohibited. Handle only in licensed research settings in accordance with applicable laws and institutional protocols.
| Weight | 3 lbs |
|---|
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