IGF-1 DES 1 mg
$55.95
IGF-1 DES (Des(1-3)IGF-1) is a naturally occurring, endogenous truncated form of IGF-1 lacking the first three N-terminal amino acids. This truncation reduces IGFBP affinity by approximately 10-fold relative to native IGF-1 while modestly increasing IGF-1 receptor binding potency. The shorter half-life and higher… CAS: 112603-35-7 | Formula: C319H501N91O96S7 | Content: 1 mg per vial | Research use only | Third-party lab tested.
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IGF-1 DES 1 mg — Research Overview
IGF-1 DES (Des(1-3)IGF-1) is a naturally occurring, endogenous truncated form of IGF-1 lacking the first three N-terminal amino acids. This truncation reduces IGFBP affinity by approximately 10-fold relative to native IGF-1 while modestly increasing IGF-1 receptor binding potency. The shorter half-life and higher local potency of IGF-1 DES make it a useful research tool for studying IGF-1R activation dynamics distinct from the longer-acting IGF-1 LR3 analogue.
- High Purity – 99% Purity Guaranteed
- Independently Lab Tested
- Research Grade Quality
- For Laboratory Research Use Only
Intended use: This material is supplied for laboratory and in-vitro research only. It is not a drug, food, or cosmetic and is not intended for human or animal consumption.
IGF-1 DES 1 mg Chemical Properties
| Property | Specification |
|---|---|
| Chemical Formula | C319H501N91O96S7 |
| Synonyms | IGF1 Human Des1-3; Insulin-Like Growth Factor 1 Des (1-3) Human Recombinant; Somatomedin C; IGF-I; IGFI; IGF1; IGF-IA; Des(1-3); Des1-3; Des 1-3; Des (1-3); IGF-1 (4-70); IGF1 Des1-3 |
| Molar Mass | 7,649 g/mol |
| CAS Number | 112603-35-7 |
| Total Compound Content | 1 mg per vial |
| Shelf Life | 36 months |
IGF-1 DES 1 mg Research Applications
IGF-1 DES is a truncated analogue of insulin-like growth factor 1 (IGF-1) in which the three N-terminal amino acids are absent relative to the full-length peptide. This structural modification alters its interaction profile with insulin-like growth factor binding proteins (IGFBPs), resulting in a greater proportion of unbound peptide available for receptor interaction. IGF-1 DES retains high-affinity binding to the insulin-like growth factor 1 receptor (IGF-1R) and preserves activation of downstream receptor-mediated signaling pathways, including PI3K/Akt/mTOR and MAPK/ERK cascades. The modified structure and distinct receptor-accessibility profile make IGF-1 DES a valuable research tool for investigating IGF-1R pharmacology, ligand-receptor interactions, growth factor signaling mechanisms, and comparative studies of IGF-1 analogues. Supplied as a lyophilized preparation (1 mg/vial). Independently third-party HPLC-tested; COA available per batch.
IGF-1 DES 1 mg Frequently Asked Questions
How does IGF-1 DES differ from IGF-1 LR3 in terms of receptor interaction characteristics?
IGF-1 DES and IGF-1 LR3 are structurally modified forms of IGF-1 that differ in their interactions with insulin-like growth factor binding proteins (IGFBPs) and their resulting receptor-accessibility profiles. IGF-1 DES utilizes N-terminal truncation, whereas IGF-1 LR3 incorporates amino acid substitution and sequence extension. These structural differences make both compounds useful research tools for investigating IGFBP interactions, ligand-receptor dynamics, and comparative IGF-1 receptor pharmacology.
What distinguishes IGF-1 DES from full-length IGF-1?
IGF-1 DES is a truncated analogue of IGF-1 in which the N-terminal region has been modified relative to the full-length peptide. This structural change alters its interaction characteristics while preserving high-affinity binding to the insulin-like growth factor 1 receptor (IGF-1R). As a result, IGF-1 DES is frequently used in studies examining structure-function relationships, receptor activation mechanisms, and the influence of peptide architecture on growth factor signaling pathways.
Why is IGF-1 DES useful for growth factor signaling research?
IGF-1 DES retains activation of key IGF-1R-mediated signaling pathways, including PI3K/Akt/mTOR and MAPK/ERK regulatory cascades. Its modified structure and distinct interaction profile make it a valuable research tool for investigating ligand-receptor interactions, growth factor signaling mechanisms, receptor pharmacology, and comparative studies of IGF-1 analogues and related signaling systems.
Research Use Disclaimer
All product information is provided for educational and laboratory research reference only. Any form of introduction into humans or animals is prohibited. Handle only in licensed research settings in accordance with applicable laws and institutional protocols.
| Weight | 1 lbs |
|---|
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