Follistatin-344 1mg
Price range: $139.99 through $1,399.90
Follistatin-344 (FS-344) is the predominant isoform of follistatin, an endogenous glycoprotein that functions as a high-affinity binding protein for multiple members of the TGF-β superfamily. By sequestering ligands including activins, myostatin (GDF-8), and selected bone morphogenetic proteins (BMPs), Follistatin-344… CAS: 100043-71-8 | Formula: C203H317N55O64S1 | Content: 1 mg per vial | Research use only | Third-party lab tested.
Buy Follistatin-344 1mg – Swiss Chems USA
Follistatin-344 1mg — Research Overview
Follistatin-344 (FS-344) is the predominant isoform of follistatin, an endogenous glycoprotein that functions as a high-affinity binding protein for multiple members of the TGF-β superfamily. By sequestering ligands including activins, myostatin (GDF-8), and selected bone morphogenetic proteins (BMPs), Follistatin-344 prevents receptor engagement and downstream Smad-dependent signal transduction. Experimental studies have utilized FS-344 to investigate activin receptor signaling, myostatin-associated regulatory pathways, TGF-β superfamily biology, ligand-receptor interaction dynamics, and Smad2/3- and Smad1/5/8-mediated transcriptional regulation. Its broad ligand-binding profile and well-characterized mechanism make Follistatin-344 a valuable research tool for studies of growth factor signaling networks, extracellular ligand sequestration, pathway cross-talk within the TGF-β superfamily, and comparative investigations of myostatin and activin antagonism.
- High Purity – 99% Purity Guaranteed
- Independently Lab Tested
- Research Grade Quality
- For Laboratory Research Use Only
Intended use: This material is supplied for laboratory and in-vitro research only. It is not a drug, food, or cosmetic and is not intended for human or animal consumption.
Follistatin-344 1mg Chemical Properties
| Property | Specification |
|---|---|
| Chemical Formula | C203H317N55O64S1 |
| Synonyms | Follistatin FST-344, FS-344, Activin-binding protein |
| Molar Mass | ~35,000 g/mol |
| CAS Number | 100043-71-8 |
| PubChem CID | N/A |
| Total Compound Content | 1 mg per vial |
| Shelf Life | 36 months |
Follistatin-344 1mg Research Applications
Follistatin-344 (FS-344) is a 344-amino-acid heparin-binding glycoprotein isoform produced through alternative splicing of the FST gene. It functions as a high-affinity extracellular binding protein for multiple TGF-β superfamily ligands, including activins, myostatin (GDF-8), and selected bone morphogenetic proteins (BMPs). By sequestering these ligands prior to receptor engagement, FS-344 inhibits downstream Smad2/3- and Smad1/5/8-dependent signaling pathways and modulates TGF-β superfamily signal transduction. Experimental investigations have utilized Follistatin-344 to study activin receptor signaling, myostatin-associated regulatory pathways, ligand-receptor interaction dynamics, extracellular growth factor sequestration, and Smad-mediated transcriptional regulation. The FS-344 isoform contains a C-terminal extension that contributes to interactions with heparan sulfate-containing structures, influencing its distribution and localization characteristics relative to other follistatin isoforms. Supplied as lyophilized preparation (1 mg/vial). Independently third-party HPLC-tested; COA available per batch.
Follistatin-344 1mg Frequently Asked Questions
What is the difference between Follistatin-344 and Follistatin-315, and why does isoform matter for research?
Follistatin-344 (FS-344) and Follistatin-315 (FS-315) are alternative splice variants of the FST gene that differ in their C-terminal sequence composition. FS-344 contains an additional peptide region associated with interactions involving heparan sulfate-containing structures, influencing its localization and distribution characteristics. FS-315 lacks this extension and displays different extracellular distribution properties. These structural differences make isoform selection an important consideration in studies investigating ligand sequestration dynamics, TGF-β superfamily signaling, extracellular protein interactions, and growth factor distribution mechanisms.
Which TGF-β superfamily members does follistatin antagonize, and how selective is this interaction?
Follistatin functions as a broad-spectrum extracellular binding protein for multiple TGF-β superfamily ligands. Its highest-affinity interactions occur with activin family members, while additional binding activity has been documented for myostatin (GDF-8) and selected bone morphogenetic proteins (BMPs). Because follistatin interacts with several ligand families rather than a single target, it is widely used in studies examining activin signaling, myostatin biology, BMP-associated pathways, receptor-ligand competition, and cross-talk within TGF-β superfamily signaling networks.
What experimental evidence supports follistatin’s role in TGF-β superfamily signaling regulation?
Extensive experimental research has demonstrated that follistatin modulates TGF-β superfamily signaling through direct ligand sequestration, preventing receptor engagement and downstream Smad-dependent signal transduction. Studies utilizing recombinant protein administration, transgenic expression systems, gene-transfer approaches, and in vitro signaling models have consistently shown suppression of activin-, myostatin-, and BMP-associated signaling pathways. These findings have established follistatin as a widely used research tool for investigating extracellular growth factor regulation, ligand-neutralization mechanisms, Smad signaling networks, and TGF-β superfamily pathway biology.
Research Use Disclaimer
All product information is provided for educational and laboratory research reference only. Any form of introduction into humans or animals is prohibited. Handle only in licensed research settings in accordance with applicable laws and institutional protocols.
| Weight | 1 lbs |
|---|---|
| Follistatin 344 1Mg |
1 vial ,KIT (10 vials) |
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