Thymosin Alpha 1
Price range: $63.99 through $639.90
Thymosin Alpha 1 (Tα1) is a synthetic peptide fragment derived from prothymosin alpha, known for its role in intracellular signaling and peptide-mediated regulatory pathways. It interacts with toll-like receptors (TLRs) and major histocompatibility complex (MHC) molecules, modulating molecular signaling CAS: 62304-98-7 | Formula: C129H215N33O55 | Content: 5 mg per vial | Research use only | Third-party lab tested.
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Thymosin Alpha 1 — Research Overview
Thymosin Alpha 1 (Tα1) is a synthetic peptide fragment derived from prothymosin alpha, known for its role in intracellular signaling and peptide-mediated regulatory pathways. It interacts with toll-like receptors (TLRs) and major histocompatibility complex (MHC) molecules, modulating molecular signaling cascades.
This peptide undergoes proteolytic degradation, with primary metabolism occurring via enzymatic hydrolysis and renal clearance.
- High Purity – 99% Purity Guaranteed
- Independently Lab Tested
- Research Grade Quality
- For Laboratory Research Use Only
Intended use: This material is supplied for laboratory and in-vitro research only. It is not a drug, food, or cosmetic and is not intended for human or animal consumption.
Thymosin Alpha 1 Chemical Properties
| Property | Specification |
|---|---|
| Chemical Formula | C129H215N33O55 |
| Synonyms | Thymalfasin, Tα1 |
| Molar Mass | 3,108.26 g/mol |
| CAS Number | 62304-98-7 |
| PubChem CID | 16130571 |
| Total Compound Content | 5 mg per vial |
| Shelf Life | 36 months |
Thymosin Alpha 1 Research Applications
Thymosin Alpha-1 (Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn) is a synthetic 28-amino-acid N-terminally acetylated peptide that interacts with multiple innate immune signaling pathways, including Toll-like receptor-associated regulatory networks. Experimental investigations have examined its interactions with TLR9-, TLR2-, and MyD88-dependent signaling mechanisms, resulting in modulation of downstream transcriptional pathways including NF-κB-associated gene regulation. Research has also explored its effects on dendritic cell signaling processes, antigen-presentation pathways, cytokine-associated regulatory networks, and peptide-mediated immune communication systems. These characteristics make Thymosin Alpha-1 a valuable research tool for studies of innate immune pathway pharmacology, Toll-like receptor signaling, immunomodulatory peptide mechanisms, and coordinated immune regulatory networks. Supplied as a lyophilized preparation (5 mg/vial). Independently third-party HPLC-tested; COA available per batch.
Thymosin Alpha 1 Lab Results & Certificates of Analysis
Third-party analytical reports associated with this research compound:
Thymosin Alpha 1 Frequently Asked Questions
What is the mechanism by which Thymosin Alpha-1 interacts with innate immune signaling pathways?
Thymosin Alpha-1 has been extensively investigated for its interactions with Toll-like receptor-associated signaling networks, particularly TLR9- and TLR2-dependent pathways. Experimental studies have demonstrated activation of MyD88-dependent signaling cascades, resulting in modulation of downstream transcriptional regulators including NF-κB. These signaling interactions make Tα1 a valuable research tool for investigating pattern-recognition receptor pharmacology, innate immune signaling mechanisms, and coordinated immune regulatory networks.
How does Thymosin Alpha-1 differ from Thymosin Beta-4 (TB-500) in research applications?
Thymosin Alpha-1 and Thymosin Beta-4 are structurally distinct thymic-derived peptides with different molecular targets and signaling pathways. Thymosin Alpha-1 is primarily investigated for its interactions with innate immune signaling networks, Toll-like receptor pathways, and immunomodulatory mechanisms. Thymosin Beta-4 is characterized by its interaction with actin-associated regulatory systems and cytoskeletal signaling pathways. As a result, the two peptides are utilized in distinct areas of peptide pharmacology and mechanistic research.
What are the primary research applications of Thymosin Alpha-1?
Thymosin Alpha-1 is widely used in studies of Toll-like receptor signaling, innate immune pathway regulation, dendritic cell-associated signaling mechanisms, cytokine regulatory networks, and peptide-mediated immune communication systems. Experimental investigations have examined its role in pattern-recognition receptor pharmacology, immune signaling pathway modulation, and coordinated interactions between innate and adaptive immune regulatory processes. These characteristics make Tα1 a valuable tool for mechanistic studies of immunomodulatory peptide pharmacology.
Research Use Disclaimer
All product information is provided for educational and laboratory research reference only. Any form of introduction into humans or animals is prohibited. Handle only in licensed research settings in accordance with applicable laws and institutional protocols.
| Thymosin Alpha 1 |
1vial 5mg ,KIT (10 vials) 50mg |
|---|
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