TB-500 Fragment (17-23)
Price range: $48.95 through $96.95
TB-500 Fragment (17-23) is a synthetic research peptide consisting of the key active amino acid sequence from the actin-binding region of thymosin beta-4. Supplied as a high-purity lyophilized powder, it’s used in laboratory research to study cellular migration, actin dynamics, angiogenic signaling, and tissue… CAS: 885340-08-9 | Formula: C38H68N10O14 | Content: 10 mg per vial | Research use only | Third-party lab tested.
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TB-500 Fragment (17-23) — Research Overview
TB-500 Fragment (17-23) is a synthetic research peptide consisting of the key active amino acid sequence from the actin-binding region of thymosin beta-4. Supplied as a high-purity lyophilized powder, it’s used in laboratory research to study cellular migration, actin dynamics, angiogenic signaling, and tissue remodeling processes.
- High Purity – 99% Purity Guaranteed
- Independently Lab Tested
- Research Grade Quality
- For Laboratory Research Use Only
Intended use: This material is supplied for laboratory and in-vitro research only. It is not a drug, food, or cosmetic and is not intended for human or animal consumption.
TB-500 Fragment (17-23) Chemical Properties
| Property | Specification |
|---|---|
| Chemical Formula | C38H68N10O14 |
| Synonyms | TB-500 Fragment (17-23), Thymosin Beta-4 Fragment 17-23, LKKTETQ |
| Molar Mass | 889.02 g/mol |
| CAS Number | 885340-08-9 |
| PubChem CID | 62707662 |
| Total Compound Content | 10 mg per vial |
| Shelf Life | 36 months |
TB-500 Fragment (17-23) Research Applications
TB-500 Fragment (17-23) is the N-acetylated seven-residue sequence (Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln) corresponding to the LKKTET actin-binding motif found at position 17–23 of Thymosin Beta-4. Because this short sequence contains the core determinant of Tβ4’s interaction with G-actin, it is frequently used in comparative studies examining whether a given cytoskeletal or signaling effect requires the full 43-residue protein or can be reproduced by the isolated binding motif alone.
Experimental work involving this fragment has focused on actin monomer sequestration assays, structure-activity mapping of the Tβ4 actin-binding domain, and mechanistic comparisons between the minimal fragment and full-length Tβ4 in cytoskeletal reorganization models. Because of its small size relative to full-length Tβ4, the fragment is also used in analytical chemistry and mass-spectrometry method development, including doping-control and peptide-identification research.
TB-500 Fragment (17-23) Frequently Asked Questions
How does TB-500 Fragment (17-23) differ from full-length TB-500/Thymosin Beta-4?
The Fragment (17-23) contains only the seven-residue LKKTET actin-binding motif that sits within the larger 43-residue Tβ4 sequence, rather than the full protein. It is typically used to test whether an observed effect of full-length Tβ4 depends on the whole protein or can be attributed to this minimal actin-binding region alone.
What is the primary research application of this fragment?
It’s used mainly in comparative actin-binding and structure-function studies, where researchers assess G-actin interaction and cytoskeletal effects of the isolated motif relative to full-length Thymosin Beta-4. It also sees use in analytical/mass-spectrometry method development for peptide identification.
Is this compound identical to commercial "TB-500"?
The name "TB-500" has been used inconsistently across the peptide supply industry — some vendors apply it to the full 43-residue Tβ4 analogue, while analytical and anti-doping literature identifies "TB-500" specifically as this Ac-LKKTETQ fragment. This listing is the isolated 7-residue fragment (CAS 885340-08-9); check formula and CAS number against any other "TB-500" product before comparing them directly.
Research Use Disclaimer
All product information is provided for educational and laboratory research reference only. Any form of introduction into humans or animals is prohibited. Handle only in licensed research settings in accordance with applicable laws and institutional protocols.
| Tb 500 Fragment 17 23 |
10mg 1vial ,5mg 1vial |
|---|
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