FTPP (Adipotide) 5mg
Price range: $63.95 through $639.50
FTPP (Adipotide) is a synthetic peptide conjugate combining a prohibitin-targeting homing sequence with a proapoptotic domain, designed to selectively engage prohibitin proteins expressed on the surface of vascular endothelial cells supplying specific tissue beds. Research interest centers on its targeted proapoptotic… CAS: 859216-15-2 | Formula: C111H206N36O28S2 | Content: 5mg (1 vial) | Research use only | Third-party lab tested.
Buy FTPP (Adipotide) 5mg – Swiss Chems USA
FTPP (Adipotide) 5mg — Research Overview
FTPP (Adipotide) is a synthetic peptide conjugate combining a prohibitin-targeting homing sequence with a proapoptotic domain, designed to selectively engage prohibitin proteins expressed on the surface of vascular endothelial cells supplying specific tissue beds. Research interest centers on its targeted proapoptotic mechanism, distinguishing it from systemically acting apoptosis-inducing compounds. Research applications include prohibitin receptor-targeting research, vascular-targeted peptide delivery studies, and adipose tissue vasculature pathway investigation.
- High Purity – 99% Purity Guaranteed
- Independently Lab Tested
- Research Grade Quality
- For Laboratory Research Use Only
Intended use: This material is supplied for laboratory and in-vitro research only. It is not a drug, food, or cosmetic and is not intended for human or animal consumption.
FTPP (Adipotide) 5mg Chemical Properties
| Property | Specification |
|---|---|
| Chemical Formula | C111H206N36O28S2 |
| Synonyms | EX-A6186, proapototic peptide |
| Molar Mass | 2557.2 g/mol |
| CAS Number | 859216-15-2 |
| PubChem CID | 163360068 |
| Total Compound Content | 5mg (1 vial) |
| Shelf Life | 36 months |
FTPP (Adipotide) 5mg Research Applications
FTPP (Adipotide) is engineered as a bifunctional peptide combining a CKGGRAKDC homing motif that binds prohibitin proteins on the surface of white adipose tissue vasculature with a proapoptotic peptide domain (KLAKLAK)2 that, once internalised via prohibitin engagement, disrupts mitochondrial membrane integrity to trigger localised apoptosis. This vascular-targeting strategy is studied as a model for tissue-selective peptide delivery, in which the homing domain confers spatial specificity while the proapoptotic payload provides the functional effect, independent of systemic apoptotic signalling. Research applications include characterising prohibitin expression patterns across vascular beds, validating the homing-domain specificity using competitive binding and biodistribution studies, and using FTPP as a tool compound for studying adipose tissue vasculature remodelling following targeted endothelial apoptosis induction. Independently third-party HPLC-tested; COA available per batch.
FTPP (Adipotide) 5mg Frequently Asked Questions
Q: What is the mechanistic basis of FTPP’s prohibitin-targeted homing strategy?
FTPP incorporates a CKGGRAKDC peptide sequence that binds selectively to prohibitin, a protein expressed on the luminal surface of vascular endothelial cells supplying white adipose tissue at higher density than in many other vascular beds. This homing domain directs the conjugated proapoptotic payload specifically to prohibitin-expressing endothelium, providing a model system for studying tissue-selective vascular targeting strategies based on differential surface receptor expression rather than systemic drug distribution.
How does the proapoptotic (KLAKLAK)2 domain in FTPP induce localized cell death once internalized?
The (KLAKLAK)2 domain is a synthetic cationic amphipathic peptide that, upon cellular internalisation following prohibitin-mediated binding, disrupts mitochondrial membrane integrity, triggering the intrinsic apoptotic pathway in the targeted endothelial cell. Because this proapoptotic domain only reaches functionally relevant intracellular concentrations following prohibitin-dependent uptake, the overall mechanism is studied as a model for spatially restricted apoptosis induction, with cell death confined largely to cells expressing the target receptor at sufficient density.
What experimental approaches validate prohibitin-targeting specificity in FTPP research?
Competitive binding assays using free prohibitin-binding peptide (without the proapoptotic payload) to block FTPP uptake, alongside biodistribution studies tracking labeled FTPP localisation across different vascular beds, are standard methods for confirming the homing domain’s binding specificity. Comparative studies using a scrambled or non-binding control peptide sequence conjugated to the same proapoptotic domain are also used to confirm that observed effects depend on the specific prohibitin-targeting sequence rather than nonspecific peptide uptake or toxicity.
Research Use Disclaimer
All product information is provided for educational and laboratory research reference only. Any form of introduction into humans or animals is prohibited. Handle only in licensed research settings in accordance with applicable laws and institutional protocols.
| Weight | 1 lbs |
|---|---|
| Ftpp Adipotide 5Mg |
1 vial ,KIT (10 vials) |
Related products
Cibinitide ARA-290 16mg
Price range: $85.60 through $855.95
Gonadorelin 2mg
Price range: $24.95 through $249.50
Kisspeptin-10 10mg
Price range: $59.99 through $599.90
Melanotan II, 10mg
Price range: $27.96 through $279.60
MGF without PEG 2mg
Price range: $29.99 through $299.90
Reviews
There are no reviews yet.