IGF-1 LR3 1mg
Price range: $59.96 through $599.60
IGF-1 LR3 (Long Arg3-IGF-1) is a synthetic 83-amino-acid analogue of insulin-like growth factor 1, engineered with an N-terminal 13-amino-acid extension and an Arg3 substitution that together confer markedly reduced affinity for IGF-binding proteins (IGFBPs) and extended plasma half-life. These modifications preserve… CAS: 143045-27-6 | Formula: C400H625N111O115S9 | Content: 1 mg per vial | Research use only | Third-party lab tested.
Buy IGF-1 LR3 1mg – Swiss Chems USA
IGF-1 LR3 1mg — Research Overview
IGF-1 LR3 (Long Arg3-IGF-1) is a synthetic 83-amino-acid analogue of insulin-like growth factor 1, engineered with an N-terminal 13-amino-acid extension and an Arg3 substitution that together confer markedly reduced affinity for IGF-binding proteins (IGFBPs) and extended plasma half-life. These modifications preserve IGF-1 receptor (IGF-1R) agonist activity while reducing IGFBP sequestration, enabling sustained receptor engagement in preclinical research models.
- High Purity – 99% Purity Guaranteed
- Independently Lab Tested
- Research Grade Quality
- For Laboratory Research Use Only
Intended use: This material is supplied for laboratory and in-vitro research only. It is not a drug, food, or cosmetic and is not intended for human or animal consumption.
IGF-1 LR3 1mg Chemical Properties
| Property | Specification |
|---|---|
| Chemical Formula | C400H625N111O115S9 |
| Synonyms | Long R3-IGF-1, M9L22Y19H9, 143045-27-6, Long-(arg3)insulin-like growth factor-i |
| Molar Mass | 9,117.60 g/mol |
| CAS Number | 143045-27-6 |
| PubChem CID | N/A |
| Total Compound Content | 1 mg per vial |
| Shelf Life | 36 months |
IGF-1 LR3 1mg Research Applications
IGF-1 LR3 is a recombinant 83-amino-acid analogue of native IGF-1 (70 AA) featuring two structural modifications: an N-terminal 13-residue extension (MFPAMPLLSLFVN) and substitution of glutamic acid at position 3 with arginine (Arg3). These changes reduce IGFBP-1 through IGFBP-6 binding affinity by approximately 1,000-fold relative to native IGF-1, effectively eliminating IGFBP sequestration and increasing the proportion of free, biologically active peptide in experimental systems. Full IGF-1R agonist activity is preserved, with downstream activation of PI3K/Akt, MAPK/ERK, and mTOR signalling cascades. Plasma half-life extends to approximately 56–72 hours versus approximately 10–20 minutes for native IGF-1. Researchers use IGF-1 LR3 to investigate IGF-1R signalling in sustained-activation contexts, anabolic pathway regulation, and the consequences of IGFBP-uncoupled IGF-1R engagement on cell proliferation, differentiation, and metabolic substrate utilisation. Supplied as lyophilised preparation (1 mg/vial). Independently third-party HPLC-tested; COA available per batch.
IGF-1 LR3 1mg Lab Results & Certificates of Analysis
Third-party analytical reports associated with this research compound:
IGF-1 LR3 1mg Frequently Asked Questions
Why does IGF-1 LR3 have a longer half-life than native IGF-1?
Native IGF-1 is rapidly sequestered in circulation by IGF-binding proteins (IGFBPs 1–6), which extend its half-life but also restrict bioavailability. The Arg3 substitution and N-terminal 13-residue extension in IGF-1 LR3 reduce IGFBP affinity by approximately 1,000-fold, preventing this sequestration. Without IGFBP binding, IGF-1 LR3 remains in free, receptor-accessible form for 56–72 hours — substantially longer than native IGF-1’s 10–20-minute half-life when not IGFBP-bound.
Which intracellular signalling pathways does IGF-1 LR3 activate via IGF-1R?
IGF-1R is a receptor tyrosine kinase. Ligand binding drives receptor autophosphorylation, IRS-1/IRS-2 adapter recruitment, and activation of two primary downstream cascades: PI3K/Akt/mTOR (governing protein synthesis, glucose uptake, and cell survival) and MAPK/ERK (regulating cell proliferation and differentiation). Both pathways are fully engaged by IGF-1 LR3 at the IGF-1R, identical to native IGF-1.
What types of experimental programs are most suited to the IGF-1 LR3 10-vial KIT format?
The IGF-1 LR3 KIT format is particularly useful for longitudinal investigations, multi-arm experimental designs, concentration-response studies, receptor-signaling experiments, and pathway-characterization programs that require repeated compound preparation over extended periods. The availability of multiple matched-batch vials supports consistent experimental conditions across separate study phases, treatment groups, and sampling timepoints. This makes the KIT format well-suited to research involving IGF-1 receptor signaling, PI3K/Akt/mTOR pathway analysis, MAPK/ERK pathway investigation, and comparative insulin-like growth factor pharmacology.
Research Use Disclaimer
All product information is provided for educational and laboratory research reference only. Any form of introduction into humans or animals is prohibited. Handle only in licensed research settings in accordance with applicable laws and institutional protocols.
| Weight | 1 lbs |
|---|---|
| Igf 1 Lr3 1Mg |
KIT (10 vials) ,Vial |
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